This research is focused on synthesizing a chiral amino aldehyde from L-Serine. The proposed synthesis of the amino aldehyde would yield a stereochemically pure product working through an L-Serine beta-lactone intermediate. The amino aldehyde is a proposed intermediate in the synthesis of (+)-obafluorin, a beta-lactone antibiotic of interest. The proposed synthesis might provide a simpler, more versatile way to synthesize obafluorin.
Cwik '96, Jim, "Pursuit of a Chiral Amino Aldehyde Intermediate in the Synthesis of (+)-Obafluorin, a B-Lactone Antibiotic" (1996). Honors Projects. 15.