Acetylcholinesterase is the enzyme that catalyzes the hydrolysis of acetylcholine. Based on the transition state of the catalysis, and what is known about the structure of the enzyme, a synthetic study has been conducted on an organophosphorous inhibitor which is capable of probing into the stereospecificity of the enzyme. The asymmetric synthesis was initiated with I-proline, and several methods were employed in phosphorylation in order to get the desired product.
Jhaveri '94, Sulay, "A Synthetic Study of an Organophosphorous Compound as an Acetylcholinesterase Inhibitor" (1994). Honors Projects. Paper 18.