Event Title

Effects of Good Limb Training on Motor Recovery Following Stroke in C57BL/6 Mice

Graduation Year

2013

Location

Atrium, Center for Natural Sciences, Illinois Wesleyan University

Start Date

20-4-2013 9:00 AM

End Date

20-4-2013 10:00 AM

Description

Upper limb impairment is a common and chronic consequence of stroke that may lead to overreliance on the good limb (GL). Although functionally adaptive, this compensatory strategy may limit recovery of the bad limb (BL). Previous research has established that GL training in mice impairs recovery of the BL following stroke in the short term. This study extends these findings by determining that GL use following stroke prevents functional recovery in the long term. Mice underwent pre-operative training on the Pasta Matrix Reaching Task. Unilateral stroke was then induced through intracortical infusions of endothelin-1. Post-operative training of the GL (or control procedures) occurred for two weeks after stroke. Following post-operative training, all mice received rehabilitative training of the BL for 28 days. Throughout rehabilitative training, control mice exhibited functional recovery while impairment persisted in GL mice. These findings suggest permanent damage to neural activity following post-stroke behavioral compensation.

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Apr 20th, 9:00 AM Apr 20th, 10:00 AM

Effects of Good Limb Training on Motor Recovery Following Stroke in C57BL/6 Mice

Atrium, Center for Natural Sciences, Illinois Wesleyan University

Upper limb impairment is a common and chronic consequence of stroke that may lead to overreliance on the good limb (GL). Although functionally adaptive, this compensatory strategy may limit recovery of the bad limb (BL). Previous research has established that GL training in mice impairs recovery of the BL following stroke in the short term. This study extends these findings by determining that GL use following stroke prevents functional recovery in the long term. Mice underwent pre-operative training on the Pasta Matrix Reaching Task. Unilateral stroke was then induced through intracortical infusions of endothelin-1. Post-operative training of the GL (or control procedures) occurred for two weeks after stroke. Following post-operative training, all mice received rehabilitative training of the BL for 28 days. Throughout rehabilitative training, control mice exhibited functional recovery while impairment persisted in GL mice. These findings suggest permanent damage to neural activity following post-stroke behavioral compensation.