Event Title

Effects of Exercise on Stroke recovery in C57BL/6 Mice

Graduation Year

2014

Location

Atrium, Center for Natural Sciences, Illinois Wesleyan University

Start Date

20-4-2013 2:00 PM

End Date

20-4-2013 3:00 PM

Description

Stroke is one of the leading causes of disability worldwide. There is increasing interest in the understanding of basic mechanisms of stroke recovery through animal models. It has been demonstrated that exercise promotes neuroplasticity that results in improved learning in humans and animals. However, exercise also induces apoptosis due to the initial metabolic strain on the CNS. This study explores the use of an exercise supplemented regimen of skilled reaching to promote functional recovery following stroke in mice. Twenty-four mice received 19 days of pre-operative training on the pasta matrix reaching task. Beginning four days after stroke, mice were separated into four groups (control, exercise, skilled reaching, and exercise + skilled reaching) for three weeks. During this time both exercise and skilled learning were used as rehabilitative strategies. Functional recovery was assessed once weekly during rehabilitation. All post-stroke reaching function was compared to pre-operative levels.

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Apr 20th, 2:00 PM Apr 20th, 3:00 PM

Effects of Exercise on Stroke recovery in C57BL/6 Mice

Atrium, Center for Natural Sciences, Illinois Wesleyan University

Stroke is one of the leading causes of disability worldwide. There is increasing interest in the understanding of basic mechanisms of stroke recovery through animal models. It has been demonstrated that exercise promotes neuroplasticity that results in improved learning in humans and animals. However, exercise also induces apoptosis due to the initial metabolic strain on the CNS. This study explores the use of an exercise supplemented regimen of skilled reaching to promote functional recovery following stroke in mice. Twenty-four mice received 19 days of pre-operative training on the pasta matrix reaching task. Beginning four days after stroke, mice were separated into four groups (control, exercise, skilled reaching, and exercise + skilled reaching) for three weeks. During this time both exercise and skilled learning were used as rehabilitative strategies. Functional recovery was assessed once weekly during rehabilitation. All post-stroke reaching function was compared to pre-operative levels.