Event Title

Aerobic Exercise as a Rehabilitative Strategy Following Inschemic Stroke in Aged C57BL/6 Mice

Graduation Year

2015

Location

Center for Natural Sciences, Illinois Wesleyan University

Start Date

18-4-2015 9:00 AM

End Date

18-4-2015 10:00 AM

Description

Current stroke rehabilitative strategies fail to yield complete recovery in patients. Further, these strategies require intensive training that is not often feasible for patients. Because aerobic exercise is neuroprotective, it has been explored as a means to promote better functional outcome post-stroke. Exercise is also an appealing rehabilitative strategy because it requires less intensity and clinician oversight than traditional therapy. This study investigated the efficacy of post-stroke exercise in an aged-mouse model of stroke. Mice were trained on a skilled reaching task before receiving focal ischemic stroke affecting their dominant limb. Following stroke, the mice were subdivided into four different groups for rehabilitative training including traditional focused rehabilitation of the impaired limb, aerobic exercise, a combination of focused rehabilitation and exercise, and a control group. Results suggest that exercise is as beneficial as traditional rehabilitative training for functional outcome, indicating that exercise may be a beneficial rehabilitative strategy in humans.

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Apr 18th, 9:00 AM Apr 18th, 10:00 AM

Aerobic Exercise as a Rehabilitative Strategy Following Inschemic Stroke in Aged C57BL/6 Mice

Center for Natural Sciences, Illinois Wesleyan University

Current stroke rehabilitative strategies fail to yield complete recovery in patients. Further, these strategies require intensive training that is not often feasible for patients. Because aerobic exercise is neuroprotective, it has been explored as a means to promote better functional outcome post-stroke. Exercise is also an appealing rehabilitative strategy because it requires less intensity and clinician oversight than traditional therapy. This study investigated the efficacy of post-stroke exercise in an aged-mouse model of stroke. Mice were trained on a skilled reaching task before receiving focal ischemic stroke affecting their dominant limb. Following stroke, the mice were subdivided into four different groups for rehabilitative training including traditional focused rehabilitation of the impaired limb, aerobic exercise, a combination of focused rehabilitation and exercise, and a control group. Results suggest that exercise is as beneficial as traditional rehabilitative training for functional outcome, indicating that exercise may be a beneficial rehabilitative strategy in humans.