Spinal Cord Stimulation for Analgesia: Measurements of Evoked Compound Action Potentials in a Rodent Model of Chronic Pain

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Chronic pain affects up to 10% of people worldwide. One treatment for chronic pain is spinal cord stimulation (SCS), which utilizes an implantable medical device that sends electrical signals to electrodes implanted in the dorsal horn of the spinal cord. It is an effective treatment for chronic pain when other medications are intolerable or ineffective. However, when patients sit or lay down, the spinal cord electrodes can get too close to the spinal cord and result in a phenomenon called postural overstimulation. Postural overstimulation can result in an unpleasant tingling sensation, or paraesthesia, near the site of stimulation. A new type of SCS called closed loop SCS can help reduce the incidence of postural overstimulation by using real time feedback, or evoked compound action potentials (ECAPs), from spinal cord tissue to modulate stimulation intensity. The purpose of this study is to assess if ECAPs can be accurately recorded in a rat SCS model. The present study was able to isolate sources of noise in order to obtain a clean ECAP signal. Secondly, the study identified an optimal electrode assembly to record ECAPs. Third, the study found an optimal electrode configuration to balance ECAP signal to noise ratio.


Biology | Neuroscience and Neurobiology

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