Graduation Year

2012

Location

Atrium, Center for Natural Sciences, Illinois Wesleyan University

Start Date

14-4-2012 9:00 AM

End Date

14-4-2012 10:00 AM

Description

Cerebral hypoxia-ischemia in human infants presents a complex clinical problem in that no standardized treatment currently exists. With an understanding of the cellular and metabolic changes brought about during hypoxia-ischemia in the immature brain, researchers can better understand the course of damage caused by ischemia. Such damage was induced in young rats in an attempt to learn more about the mechanisms of hypoxia-ischemia. Seven-day-old rat pups underwent permanent unilateral carotid artery ligation and then were exposed to systemic hypoxia. At 15 days of postnatal age, researchers used neuropathologic analysis, gross examination, and staining of brain slices to assess the severity of damage from hypoxia-ischemia. Hypoxic preconditioning appeared to reduce or prevent tissue damage during a subsequent hypoxic-ischemic event.

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Apr 14th, 9:00 AM Apr 14th, 10:00 AM

Hypoxia-Ischemia in the Immature Brain and Mechanisms of Reducing Tissue Damage

Atrium, Center for Natural Sciences, Illinois Wesleyan University

Cerebral hypoxia-ischemia in human infants presents a complex clinical problem in that no standardized treatment currently exists. With an understanding of the cellular and metabolic changes brought about during hypoxia-ischemia in the immature brain, researchers can better understand the course of damage caused by ischemia. Such damage was induced in young rats in an attempt to learn more about the mechanisms of hypoxia-ischemia. Seven-day-old rat pups underwent permanent unilateral carotid artery ligation and then were exposed to systemic hypoxia. At 15 days of postnatal age, researchers used neuropathologic analysis, gross examination, and staining of brain slices to assess the severity of damage from hypoxia-ischemia. Hypoxic preconditioning appeared to reduce or prevent tissue damage during a subsequent hypoxic-ischemic event.