Title of Presentation or Performance

Elsker : A new bacteriophage to combat antibiotic resistant Enterobacter

Presenter and Advisor Information

Rachel Maurer, Illinois Wesleyan University

Type of Submission

Poster

Type of Submission (Archival)

Event

Area of Study or Work

Biology

Faculty Advisor

David Bollivar

Expected Graduation Date

2019

Location

Center for Natural Sciences, Illinois Wesleyan University

Start Date

4-13-2019 9:00 AM

End Date

4-13-2019 10:00 AM

Disciplines

Education

Abstract

The World Health Organization has called bacterial antibiotic resistance one of the biggest threats to global health. The rise of antibiotic resistance and the laborious process of creating new antibiotics has led to a resurgence of interest in combating bacterial infections with bacteriophages. Bacteriophages are viruses that infect and kill specific strains of bacteria. Phages kill specific bacterial hosts, unlike broad spectrum antibiotics which kill not only the pathogenic bacteria but bacteria that make up the healthy microbiome. Phage therapy has recently been used to combat multidrug resistant (MDR) bacteria, but wider application will require the identification of more novel bacteriophages. Bacteria in the Enterobacter genus are an example of clinically relevant bacteria displaying broad MDR. Few antibiotics are effective against highly resistant Enterobacter species, which cause infection of the bloodstream and urinary and respiratory tracts. The goal of this study was to isolate and characterize a bacteriophage that could infect and kill a non-pathogenic model Enterobacter. Pre-filtration water samples were collected from the Bloomington-Normal Water Reclamation District. The Enterobacter aerogenes specific-phage, known as Elsker, underwent enrichment and isolation. The next steps in this project will be to characterize Elsker by genome sequencing and transmission electron microscopy (TEM).

This document is currently not available here.

Share

COinS
 
Apr 13th, 9:00 AM Apr 13th, 10:00 AM

Elsker : A new bacteriophage to combat antibiotic resistant Enterobacter

Center for Natural Sciences, Illinois Wesleyan University

The World Health Organization has called bacterial antibiotic resistance one of the biggest threats to global health. The rise of antibiotic resistance and the laborious process of creating new antibiotics has led to a resurgence of interest in combating bacterial infections with bacteriophages. Bacteriophages are viruses that infect and kill specific strains of bacteria. Phages kill specific bacterial hosts, unlike broad spectrum antibiotics which kill not only the pathogenic bacteria but bacteria that make up the healthy microbiome. Phage therapy has recently been used to combat multidrug resistant (MDR) bacteria, but wider application will require the identification of more novel bacteriophages. Bacteria in the Enterobacter genus are an example of clinically relevant bacteria displaying broad MDR. Few antibiotics are effective against highly resistant Enterobacter species, which cause infection of the bloodstream and urinary and respiratory tracts. The goal of this study was to isolate and characterize a bacteriophage that could infect and kill a non-pathogenic model Enterobacter. Pre-filtration water samples were collected from the Bloomington-Normal Water Reclamation District. The Enterobacter aerogenes specific-phage, known as Elsker, underwent enrichment and isolation. The next steps in this project will be to characterize Elsker by genome sequencing and transmission electron microscopy (TEM).