Previous studies on panic disorfer (Bruce et al., 1995) have examined predictors of relapse on a short-term basis. This study investigated predictors of relapse and long-term recovery in panic disorder treated with alprazolam or alprazolam plus cognitive behavior therapy (CBT). Relapse was defined as return to medication or other treatment after discontinuation. Logistic regression analysis tested five variables derived from different conceptualizations of panic disorder etiology and treatment to determine if any predictors of relapse versus long-term recovery could be found. Only the change in Anxiety Sensitivity Index score from baseline to posttaper was found to be significant(p < 0.05, B= 0.22, df=1, R=0.25). this univariate model correctly classified 73 percent of patient outcomes at a two to four year followup. this finding suggests that a focus on cognitive change during treatment may help prevent relapse. Future research should include controlled studies to isolate the mechanism of cognitive change.



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