The Effect of Spinal Cord Stimulation for Chronic Pain Treatment
Submission Type
Event
Faculty Advisor
Joe Williams
Expected Graduation Date
2019
Location
Center for Natural Sciences, Illinois Wesleyan University
Start Date
4-13-2019 2:00 PM
End Date
4-13-2019 3:00 PM
Disciplines
Education
Abstract
Spinal Cord Stimulation (SCS) is a form of therapy to treat forms of chronic pain. Although the efficacy of SCS treatment is relatively positive and is used clinically, the neurobiological mechanisms behind this treatment are not fully understood. The present study uses an animal model of chronic pain, involving transection of the sciatic nerve of one paw, to measure whether there are changes in the expression of following injury and subsequent SCS treatment. The study also examines the efficacy of different forms of SCS treatment by changing stimulation parameters (cathodic, anodic, symmetrical and asymmetrical stimulation parameters) and examines whether the degree of pain relief exhibited with each treatment correlates with changes in gene expression.
The Effect of Spinal Cord Stimulation for Chronic Pain Treatment
Center for Natural Sciences, Illinois Wesleyan University
Spinal Cord Stimulation (SCS) is a form of therapy to treat forms of chronic pain. Although the efficacy of SCS treatment is relatively positive and is used clinically, the neurobiological mechanisms behind this treatment are not fully understood. The present study uses an animal model of chronic pain, involving transection of the sciatic nerve of one paw, to measure whether there are changes in the expression of following injury and subsequent SCS treatment. The study also examines the efficacy of different forms of SCS treatment by changing stimulation parameters (cathodic, anodic, symmetrical and asymmetrical stimulation parameters) and examines whether the degree of pain relief exhibited with each treatment correlates with changes in gene expression.