Spinal Cord Stimulation For Analgesia: Measurements of Evoked Compound Action Potentials in a Rodent Model of Chronic Pain
Major
Neuroscience
Submission Type
Poster
Area of Study or Work
Neuroscience
Expected Graduation Date
2023
Location
CNS Atrium, Easel 20
Start Date
4-15-2023 10:30 AM
End Date
4-15-2023 11:45 AM
Abstract
Chronic pain affects up to 10% of people worldwide. Most people with chronic pain respond to medications such as opioids, but opioids can be limited by efficacy, side effects, tolerance, and dependence. An alternate treatment for chronic pain is spinal cord stimulation (SCS), utilizing an implantable medical device that sends electrical signals to electrodes implanted in the dorsal horn of the spinal cord. It is an effective treatment for chronic pain when other medications are intolerable or ineffective. However, when patients sit or lay down, the spinal cord electrodes can get too close to the spinal cord and result in a phenomenon called postural overstimulation. Postural overstimulation can result in an unpleasant tingling sensation, or paraesthesia, near the site of stimulation. A new type of SCS called closed loop SCS can help reduce the incidence of postural overstimulation by using real time feedback, or evoked compound action potentials, from spinal cord tissue to modulate stimulation intensity. The purpose of this study is to assess how evoked compound action potentials, or ECAPs, can be used as real time feedback from the spinal cord and reduce postural overstimulation.
Spinal Cord Stimulation For Analgesia: Measurements of Evoked Compound Action Potentials in a Rodent Model of Chronic Pain
CNS Atrium, Easel 20
Chronic pain affects up to 10% of people worldwide. Most people with chronic pain respond to medications such as opioids, but opioids can be limited by efficacy, side effects, tolerance, and dependence. An alternate treatment for chronic pain is spinal cord stimulation (SCS), utilizing an implantable medical device that sends electrical signals to electrodes implanted in the dorsal horn of the spinal cord. It is an effective treatment for chronic pain when other medications are intolerable or ineffective. However, when patients sit or lay down, the spinal cord electrodes can get too close to the spinal cord and result in a phenomenon called postural overstimulation. Postural overstimulation can result in an unpleasant tingling sensation, or paraesthesia, near the site of stimulation. A new type of SCS called closed loop SCS can help reduce the incidence of postural overstimulation by using real time feedback, or evoked compound action potentials, from spinal cord tissue to modulate stimulation intensity. The purpose of this study is to assess how evoked compound action potentials, or ECAPs, can be used as real time feedback from the spinal cord and reduce postural overstimulation.