Spinal cord stimulation and differential target multiplexed programming
Major
Psychology
Submission Type
Poster
Area of Study or Work
Neuroscience, Psychology
Faculty Advisor
Joe Williams
Expected Graduation Date
2027
Location
CNS Atrium
Start Date
4-12-2025 8:30 AM
End Date
4-12-2025 9:30 AM
Abstract
Spinal cord stimulation (SCS) is a treatment for people who suffer chronic pain conditions, such as chronic back pain. SCS involves implanting an electrode directly into the spinal cord to send electrical impulses. This treatment has proven to be clinically effective for people who have been suffering with pain. However, the continuous use of (SCS) has shown some issues such as faster battery depletion which could ultimately decrease the efficacy of the SCS treatment. In this research, we are testing an alternate method using two differential target multiplexed programming (DTMP) models to determine whether the new methodology is 1) as efficacious and 2) works via a different biological mechanism than the continuous low-rate SCS treatment. DTMP treatments significantly decreased mechanical hypersensitivity in the SNI animal model of neuropathic pain, with the DTMP models having a significantly higher efficacy in pain reduction in comparison to continuous low-rate SCS. In addition, the DTMP models modulate different genes than the continuous low-rate SCS treatment, indicating that DTMP works by a different biological mechanism.
Spinal cord stimulation and differential target multiplexed programming
CNS Atrium
Spinal cord stimulation (SCS) is a treatment for people who suffer chronic pain conditions, such as chronic back pain. SCS involves implanting an electrode directly into the spinal cord to send electrical impulses. This treatment has proven to be clinically effective for people who have been suffering with pain. However, the continuous use of (SCS) has shown some issues such as faster battery depletion which could ultimately decrease the efficacy of the SCS treatment. In this research, we are testing an alternate method using two differential target multiplexed programming (DTMP) models to determine whether the new methodology is 1) as efficacious and 2) works via a different biological mechanism than the continuous low-rate SCS treatment. DTMP treatments significantly decreased mechanical hypersensitivity in the SNI animal model of neuropathic pain, with the DTMP models having a significantly higher efficacy in pain reduction in comparison to continuous low-rate SCS. In addition, the DTMP models modulate different genes than the continuous low-rate SCS treatment, indicating that DTMP works by a different biological mechanism.