Iron(II) triflate catalyzed synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the Biginelli reaction
Major
Chemistry
Submission Type
Poster
Area of Study or Work
Chemistry
Faculty Advisor
Mohan
Location
CNS Atrium
Start Date
4-11-2026 8:30 AM
End Date
4-11-2026 9:45 AM
Abstract
Dihydropyrimidinone scaffolds have attracted attention due to their biological activities and ease of construction. The most common pathway to these molecules is the Biginelli reaction, a multicomponent reaction involving an aldehyde, urea and a β-keto ester. This one-pot reaction is usually catalyzed by a Brønsted or Lewis acid. Many catalysts have been reported for the Biginelli reaction, such as FeCl3, TaBr5, and TiCp2Cl2. Some of these catalysts are toxic, not environmentally friendly, and hard to handle. Iron(III) and iron(II) salts are effective Lewis acid catalysts in various organic transformations, but iron(II) salts are less explored. Iron(II) triflate is relatively inexpensive, easy to handle, and nontoxic, making it attractive from a green chemistry perspective. We report the use of iron(II) triflate as an efficient catalyst for the Biginelli reaction.
Iron(II) triflate catalyzed synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the Biginelli reaction
CNS Atrium
Dihydropyrimidinone scaffolds have attracted attention due to their biological activities and ease of construction. The most common pathway to these molecules is the Biginelli reaction, a multicomponent reaction involving an aldehyde, urea and a β-keto ester. This one-pot reaction is usually catalyzed by a Brønsted or Lewis acid. Many catalysts have been reported for the Biginelli reaction, such as FeCl3, TaBr5, and TiCp2Cl2. Some of these catalysts are toxic, not environmentally friendly, and hard to handle. Iron(III) and iron(II) salts are effective Lewis acid catalysts in various organic transformations, but iron(II) salts are less explored. Iron(II) triflate is relatively inexpensive, easy to handle, and nontoxic, making it attractive from a green chemistry perspective. We report the use of iron(II) triflate as an efficient catalyst for the Biginelli reaction.